Status:
UNKNOWN
Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke
Lead Sponsor:
Capital Medical University
Conditions:
Acute Stroke
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
PHASE3
Brief Summary
Currently, dual antiplatelet therapy with aspirin and clopidogrel (with loading doses) is widely used for patients with acute ischemic stroke. However, immediate, potent and reversible inhibition of p...
Eligibility Criteria
Inclusion
- Acute ischemic stroke with 24 hours of symptom onset.
- NIHSS≥4 and ≤20 points, and the paralyzed limbs is able to actively move the muscle (standardized motor examination rating scale of 2 or much higher).
- Age 18-80 years old.
- Informed consent obtained from patient or acceptable patient's surrogate.
Exclusion
- Treated with intravenous or endovascular thrombectomy for the indexed acute ischemic stroke.
- Acute ischemic stroke caused by determined or suspected cardioembolism.
- Acute ischemic stroke caused by other determined caused, including moyamoya disease, artery dissection, arteritis, and etc.
- Pre-stroke mRS ≥2 or the paralyzed limbs are dyskinesia before stroke.
- Known hematochezia, gastrointestinal bleeding and any other bleeding.
- Allergy to tirofiban or its solvents.
- Patients suffered from severe diseases, including malignant tumor, liver cirrhosis, kidney failure, congestive heart failure, and etc.
- Gastrointestinal or genitourinary tract bleeding within 1 years.
- Determined coagulation disorders, platelet dysfunction, or platelet count \<100\*109/L.
- Major surgical operation or severe trauma within 1 month.
- Hemorrhagic retinopathy.
- Chronic hemodialysis.
- Uncontrolled hypertension with systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg.
- Acute pericarditis.
- Other conditions that determined by the investigators.
Key Trial Info
Start Date :
September 12 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2023
Estimated Enrollment :
420 Patients enrolled
Trial Details
Trial ID
NCT04491695
Start Date
September 12 2020
End Date
March 31 2023
Last Update
July 19 2022
Active Locations (19)
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1
Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100053
2
Beijing Luhe Hospital, Capital Medical University
Beijing, Beijing Municipality, China
3
The first Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
4
Nanyang Central Hospital
Nanyang, Henan, China