Status:
RECRUITING
Deciphering Preserved Autonomic Function After Spinal Cord Injury
Lead Sponsor:
Mayo Clinic
Conditions:
Spinal Cord Injuries
Autonomic Imbalance
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin b...
Detailed Description
This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. To accomplish this, we are enrolling both individuals with and without spinal cord i...
Eligibility Criteria
Inclusion
- All subjects
- \- age 18-50 years old.
- Participants with spinal cord injury
- Adult onset, traumatic spinal cord injury.
- American Spinal Injury Association Impairment Scale, A-D, to encompass a spectrum of autonomic dysfunction after spinal cord injury.
- Neurological level of injury, C1-T12, as defined by the International Standards for Neurological Classification of Spinal Cord Injury. Incorporating level of injury down to T12 to encompass a broad range of autonomic dysfunction.
Exclusion
- History of cardiovascular disease, hypertension, neurologic disorders (with exception of spinal cord injury), or diabetes.
- Women who are pregnant or lactating.
- Currently taking blood thinners.
- Pacemaker, implanted defibrillator, or intrathecal pump incompatible with MRI scanning.
- Cognitive issues preventing informed consent for participation.
- Body mass index \>30 kg/m2 for controls, in an effort to limit effects of early cardiovascular disease and diabetes in control population. Body mass index has not proven to be a good estimate of these factors following spinal cord injury.
Key Trial Info
Start Date :
November 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT04493372
Start Date
November 13 2020
End Date
December 31 2025
Last Update
September 30 2025
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55902