Status:
RECRUITING
Serial Tumour Biopsies and Blood Biomarkers in Melanoma
Lead Sponsor:
The Christie NHS Foundation Trust
Collaborating Sponsors:
University of Manchester
Conditions:
Melanoma
Eligibility:
All Genders
16+ years
Brief Summary
Recent advances in understanding how cancer develops and spreads have led to effective new treatments and improved outcomes for patients with melanoma. However, we know that these new treatments do no...
Detailed Description
This will be a prospective study recruiting patients who have been diagnosed wth advanced melanoma. Participants will be asked to give informed consent before any samples are collected. Participants...
Eligibility Criteria
Inclusion
- Age of 16 years or more.
- Patients must have given written informed consent.
- Evidence of locally advanced or metastatic melanoma, i.e. stage III or IV disease.
- Accessible tumour that can be safely biopsied using radiological or surgical techniques (if consenting to part A).
- Full blood count and coagulation tests within acceptable parameters (if consenting to part A).
Exclusion
- Inability to provide informed consent.
- History of significant bleeding disorder (patients on anticoagulation are eligible if the anticoagulation can be safely managed to allow fresh tumour biopsies and blood sampling).
- History of HIV, Hepatitis B/C or other transmissible human disease.
- Any conditions where research biopsies or blood sampling may increase risk of complications for the patient and/or investigator, including high risk groups such as intravenous drug users.
Key Trial Info
Start Date :
November 14 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2034
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04493723
Start Date
November 14 2018
End Date
July 1 2034
Last Update
July 30 2020
Active Locations (1)
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1
The Christie
Manchester, United Kingdom, M20 4BX