Status:
COMPLETED
Sympathetic Activity and Cardiometabolic Complications
Lead Sponsor:
University of Turin, Italy
Conditions:
Catecholamine; Overproduction
Catecholamine; Secretion
Eligibility:
All Genders
18+ years
Brief Summary
Recent studies on catecholamine physiology have shown a direct correlation with arterial hypertension, overcoming the exclusive role in the diagnosis and follow-up of chromaffin tumors. Nevertheless,...
Detailed Description
Catecholamines (noradrenaline, adrenaline and dopamine) are adaptive and maladaptive stress hormones. In the classic "fight or flight" mechanism, they activate behavioral and physiological processes ...
Eligibility Criteria
Inclusion
- Measurement of 24h urinary metanephrines at the laboratory of "City of Health and Science" hospital in Turin between 2007 and 2015
- Availability of contextual clinical patient data as collected in prospective registries of Piedmont region
Exclusion
- Diagnosis of pheochromocytoma or paraganglioma (at the time of urinary metanephrines collection or within the following 5 years)
- Diagnosis of other forms of secondary hypertension
- Previous cardiovascular or cerebrovascular event
- Chronic heart failure
- eGFR \< 50 ml/min (according to CKD-EPI)
- Liver cirrhosis
- Acute conditions and/or hospitalization in ICU (at the time of urinary metanephrines collection)
- Assumption of acetaminophen during the day before the 24-hour urine collection
- Therapy with labetalol
- Therapy with sotalol
- Therapy with alpha-methyldopa
- Therapy with MAO inhibitors
- Therapy with tricyclic antidepressants
- Therapy with buspirone
- Therapy with phenoxybenzamine
- Therapy with sulfasalazine
- Therapy with L-Dopa
- Therapy with sympathomimetic drugs or other vasopressors
- Alcohol abuse
- Cocaine abuse
Key Trial Info
Start Date :
September 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2020
Estimated Enrollment :
1380 Patients enrolled
Trial Details
Trial ID
NCT04495231
Start Date
September 1 2007
End Date
July 1 2020
Last Update
July 31 2020
Active Locations (1)
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1
Division of Endocrinology, Diabetology and Metabolism; University of Turin
Turin, Piedmont, Italy, 10126