Status:
UNKNOWN
Fluid unLoading On Weaning (FLOW)
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Conditions:
Weaning Failure
Fluid Overload
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and ...
Detailed Description
Fluid overload is a state of global body accumulation of fluids with a deleterious impact in organ function. This condition is frequently found in critically ill patients after acute resuscitation. It...
Eligibility Criteria
Inclusion
- Mechanical ventilation for \>24 hours and \<7 days
- Patients who on the daily evaluation to assess their potential for weaning present fluid overload and, in consequence, require fluid depletion before the spontaneous breathing trial
- Clinical condition resolving or hemodynamically stable condition with acceptable ventilatory status that allows an spontaneous breathing trial according to attending's criteria.
Exclusion
- Pregnancy
- Do-not-resuscitate status
- Child B or C liver cirrhosis
- Circulatory instability
- Acute coronary syndrome
- Active bleeding
- Severe concomitant acute respiratory distress syndrome
- Malnutrition
- Muscle weakness severe enough to be considered by itself a risk for weaning failure
- Patient should be excluded based on the opinion of the clinician/investigator (documented reason)
Key Trial Info
Start Date :
July 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2023
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04496583
Start Date
July 1 2021
End Date
June 1 2023
Last Update
September 5 2021
Active Locations (1)
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1
Hospital Clínico UC CHRISTUS
Santiago, RM, Chile, 8330077