Status:
COMPLETED
Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation
Lead Sponsor:
Politecnico di Milano
Collaborating Sponsors:
Istituti Clinici Scientifici Maugeri SpA
Philips Healthcare
Conditions:
Pulmonary Disease, Chronic Obstructive
Hypercapnia
Eligibility:
All Genders
18-84 years
Phase:
NA
Brief Summary
This study aimed to evaluate the effects of a novel automatic non-invasive ventilation (NIV) mode that continuously adjusts expiratory positive airway pressure (EPAP) to the lowest value that abolishe...
Detailed Description
Study design: prospective, randomized, cross-over study. Study population: moderate to severe COPD patients, long-term users of nocturnal non-invasive ventilation for chronic hypercapnic respiratory f...
Eligibility Criteria
Inclusion
- moderate to severe COPD (GOLD 2017);
- long-term users of nocturnal non-invasive ventilation for chronic hypercapnic respiratory failure;
- presence of tidal expiratory flow limitation in the supine position at an expiratory positive airway pressure of 4 cmH2O.
Exclusion
- COPD exacerbation within the past two months;
- acute illness;
- clinical instability.
Key Trial Info
Start Date :
October 23 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 15 2018
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04497090
Start Date
October 23 2014
End Date
May 15 2018
Last Update
August 4 2020
Active Locations (1)
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1
Divisione di Pneumologia, Fondazione S. Maugeri, IRCCS
Lumezzane, BS, Italy