Status:
COMPLETED
The Clinical Efficiency of Tb-ERA in Chinese RIF Patients
Lead Sponsor:
ShangHai Ji Ai Genetics & IVF Institute
Conditions:
Endometrial Receptivity
Repeated Implantation Failure
Eligibility:
FEMALE
20-40 years
Phase:
NA
Brief Summary
In order to further explore the clinical utility of endometrial receptivity array in patients with repeated implantation failure, the patients divide into the experimental group or the control group. ...
Detailed Description
In the field of assisted reproduction techonology, there are still 10% of patients with repeated implantation failure. In order to further explore the clinical utility of endometrial receptivity array...
Eligibility Criteria
Inclusion
- People with unexplained repeated implantation failure (3 or more times of transplantation, at least 4 or more high-quality embryos failed to conceive).
- Age: 20-40 years old.
- BMI: 19 - 24.
- The thickness of endometrium is more than or equal to 7 mm.
Exclusion
- Known causes of embryo implantation failure, such as infection, reproductive tract malformation, uterine cavity factors, immune factors, hydrosalpinx, etc.
- Decreased ovarian function (meet the following at least two criteria: ① 10u / L \< basal follicle stimulating hormone (FSH) \< 25U / L, and / or estradiol (E2) \> 292.8pmol/l, and / or FSH / LH \> 3; ② the number of antral follicles \< 5-7 on the second to third day of menstruation; and (or) antimullerian hormone (AMH) \< 0.5-1.1ng/ml.
- People with genetic history.
- Those who have done abortion and the histogenetic analysis are positive.
Key Trial Info
Start Date :
November 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2024
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04497558
Start Date
November 20 2020
End Date
December 30 2024
Last Update
February 26 2025
Active Locations (1)
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1
Shanghai Ji Ai Genetics & IVF Institute, Obstetrics and Gynecology Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 200011