Status:
RECRUITING
Lymphatic Mapping Of Oropharyngeal Cancer
Lead Sponsor:
University College, London
Collaborating Sponsors:
National Institute for Health Research, United Kingdom
Conditions:
Oropharyngeal Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A multi-centre validation study to evaluate whether a new imaging and surgical protocol would work as well as the current gold standard in identifying sentinel nodes in patients with oropharyngeal can...
Detailed Description
Cancer at the back of the mouth and throat is usually discovered after it has spread to lymph glands in the neck. Treatment therefore involves dealing with both the original tumour (in the mouth/throa...
Eligibility Criteria
Inclusion
- Adults aged 18 or over
- New diagnosis of OPC - all anatomical subsites and HPV status accepted
- Unilateral metastatic nodes equating to AJCC TNM8 clinical staging N1-N2b for P16 negative and N1 for P16 positive patients.
Exclusion
- Suspicious bilateral nodes on imaging
- Previous radiotherapy or surgery to the neck
- Second primary oropharyngeal tumours
- Distant metastasis (e.g. lung, bone)
- Pregnancy and lactation
- Inability to give informed consent
- Allergy to lymphatic tracers
Key Trial Info
Start Date :
July 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04498221
Start Date
July 7 2022
End Date
January 1 2027
Last Update
September 19 2024
Active Locations (2)
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1
St George's University Hospitals NHS Foundation Trust
London, United Kingdom, SW17 0QT
2
University College Hospital
London, United Kingdom