Status:

UNKNOWN

Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure

Lead Sponsor:

University of Leipzig

Conditions:

Heart Failure With Reduced Ejection Fraction

Eligibility:

All Genders

18+ years

Brief Summary

Sacubitril-Valsartan reduced heart failure hospitalizations and cardiovascular mortality compared to enelapril in chronic heart failure. Furthermore, quality of life is improved. The decrease of NT-pr...

Eligibility Criteria

Inclusion

  • Symptomatic heart failure (NYHA functional class II to IV)
  • Reduced LV ejection fraction (≤ 40%)
  • Clinical indication for therapy with Sacubitril-Valsartan

Exclusion

  • catecholamine therapy at inclusion
  • existing therapy with Sacubitril-Valsartan
  • planned cardiac resynchronization therapy (CRT) within 6 months; inclusion at least 3 months after CRT
  • planned mitral or aortic valve procedure within 6 months; inclusion at least 3 months after valve procedure
  • participation in another randomized heart failure trial
  • severe aortic or mitral valve lesion

Key Trial Info

Start Date :

July 21 2020

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

December 31 2025

Estimated Enrollment :

117 Patients enrolled

Trial Details

Trial ID

NCT04498780

Start Date

July 21 2020

End Date

December 31 2025

Last Update

May 12 2023

Active Locations (2)

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Page 1 of 1 (2 locations)

1

University of Leipzig

Leipzig, Saxony, Germany, 04103

2

Kardiopraxis Schirmer

Kaiserslautern, Germany