Status:
UNKNOWN
Fiber Fermentation, and Short Chain Fatty Acid Kinetics and Utilization Inside the Gut and Systemic Circulation
Lead Sponsor:
Wageningen University
Conditions:
Dietary Fiber
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
Nowadays there is a strong interest in optimising human health through manipulation of non-digestible carbohydrates (NDC). NDC can be used as substrates by gut microbiota, which results in NDC degrada...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Males
- Age 18-60yrs
- BMI between 18.5 and 30 kg/m2
- Regular bowel movement (defaecation on average once a day)
- Signed informed consent
- Exclusion criteria:
- Having a history of medical or surgical events that, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results of the study (e.g. diabetes, cardiovascular disease, gastrointestinal disease, renal failure, cancer, infectious disease, nose/throat).
- Having a history of surgical events of the gastro-intestinal tract (e.g. bariatric surgery/gastric bypass surgery)
- Presence of swallowing disorder
- Use of any prescribed or non-prescribed medication (other than paracetamol) including antacids, analgesics, and herbal remedies during the three (3) weeks prior to study start.
- Being lactose intolerant
- Follows a vegan diet
- Use of antibiotics within 3 months of starting the study or planned during the study
- Use of pro- or prebiotics (e.g. galacto-oligosaccharides, fructo-oligosaccharides)
- Constipation/infrequent bowel movement (less than 3 times defaecation per week)
- Abuse of drugs/alcohol (alcohol: \>4 consumptions/day or \>21 consumptions/week)
- Smoker
- Having diarrhoea within 1 month prior to the study start
- Personnel of Wageningen University, Division of Human Nutrition, their partner and their first and second degree relatives
- Participation in another biomedical study or other research from the Division of Human Nutrition
- Not willing to be exposed to fluoroscopy
- Having a hemoglobin of \<8.5 mmol/L
- Having blood vessels that are too difficult for inserting a cannula
- Not having a general practitioner
Exclusion
Key Trial Info
Start Date :
October 8 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2021
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04499183
Start Date
October 8 2020
End Date
February 1 2021
Last Update
October 19 2020
Active Locations (1)
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1
Wageningen University and Research
Wageningen, Netherlands, 6708 WE