Status:
RECRUITING
Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
Lead Sponsor:
Sherief Abd-Elsalam
Conditions:
Esophageal Varices
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension
Detailed Description
A Randomized controlled trial of carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension
Eligibility Criteria
Inclusion
- • Aged \>18 years
- Cirrhotic patients with arterial hypertension
- Endoscopic evidence of medium/large-sized esophageal varices
Exclusion
- • History of variceal bleeding or previous primary prevention of varices.
- Portal vein thrombosis or previous porto-systemic shunts as TIPS.
- Patients on drugs affecting portal pressure (beta blockers, nitrates).
- Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, severe bradycardia.
- Patients with severe respiratory diseases (COPD, bronchial asthma).
- Uncontrolled diabetes mellitus
- Renal impairment
- Hepatocellular carcinoma
- Allergy to carvedilol
- Pregnancy or lactation
Key Trial Info
Start Date :
October 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 10 2030
Estimated Enrollment :
306 Patients enrolled
Trial Details
Trial ID
NCT04499898
Start Date
October 1 2018
End Date
December 10 2030
Last Update
August 5 2020
Active Locations (1)
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1
Sherief Abd-Elsalam
Tanta, Egypt