Status:
UNKNOWN
Serum Neurofilament Light (NFL) in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp)
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Conditions:
General Surgery
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Experimental studies have shown that inhalational anesthetics may be neurotoxic by for example causing amyloid beta deposition. Otherwise a pre-clinical study reported an increase in tau phosphorylati...
Detailed Description
POD and POCD are manifestations of cognitive dysfunction occurring in the perioperative period. Whether surgery and specifically anesthesia contribute to the development of perioperative cognitive dys...
Eligibility Criteria
Inclusion
- Adult patients undergoing thyroid or breast cancer surgery and necessitating one night of hospital stay
Exclusion
- Renal insufficiency with a GFR \< 30 mL/min
- Mammectomy
- Preoperative psychiatric problems
- Patients not speaking fluently French
- Patients at risk of postoperative hyperalgesia (Kalkman score \> 4/15)
- Allergy to local anesthetics, NSAID and to Rocuronium
- Patients undergoing one day surgery
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04500236
Start Date
September 1 2020
End Date
February 28 2023
Last Update
April 22 2022
Active Locations (1)
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1
Cliniques Universitaires Saint Luc
Brussels, Belgium, 1200