Status:
ACTIVE_NOT_RECRUITING
Training Induced Muscle Exosome Release
Lead Sponsor:
Yuan Wen
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Metabolism
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The primary objective of this study is to quantify miR-1 release from muscle in extra-cellular vesicles following an acute resistance exercise bout and potential delivery to subcutaneous adipose tissu...
Detailed Description
Numerous studies in humans and animals have shown that aerobic exercise is beneficial to adipose tissue function and whole-body metabolism. Both acute and chronic aerobic exercise enhance adipocyte ca...
Eligibility Criteria
Inclusion
- 18-30 years of age.
- Either BMI \<25 or \>30.
- Relatively sedentary, reporting no participation in regular (\>1 day per week) exercise for at least the past 3 months.
- Non-smoker.
Exclusion
- BMI between 25 and 30.
- Evidence or signs and symptoms for cardiovascular disease (previous heart attack, arrhythmias, angina, shortness of breath, extreme fatigue, unusual pain in neck, jaw, throat, upper abdomen, or back, swelling in feet, legs, or ankles).
- Evidence or signs and symptoms of metabolic syndrome or disorder (diagnosis of diabetes or insulin resistance, elevated BP, high fasting blood sugar, abnormal cholesterol or triglyceride levels).
- Chronic aspirin or NSAID use (unless it can be safely stopped prior to the biopsies), and any other use of an anticoagulant (e.g., Coumadin) or history of bleeding including history of hypo- or hyper-coagulation disorders.
- Neurological, musculoskeletal, or other disorder that would preclude safe participation in the weight lifting tasks and all performance tests.
- Any other medical condition that would interfere with testing or increase one's risk of complications during exercise, as judged by the study physician.
- Any other condition or events considered exclusionary by the PI and/or physician, such as non-compliance.
- Lidocaine allergy (1% lidocaine is the local anesthetic used during the muscle biopsy procedure).
- Pregnancy.
Key Trial Info
Start Date :
March 14 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2026
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT04500769
Start Date
March 14 2019
End Date
November 30 2026
Last Update
December 10 2024
Active Locations (1)
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1
University of Kentucky
Lexington, Kentucky, United States, 40536