Status:
RECRUITING
Natural History of Autosomal Dominant Hearing Loss
Lead Sponsor:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Hearing Loss
Eligibility:
All Genders
3-99 years
Brief Summary
Background: Hereditary hearing loss is one of the most common sensory disabilities affecting newborns. The main options for people with hereditary hearing loss are hearing aids and cochlear implants....
Detailed Description
Hereditary hearing loss is one of the most common sensory disabilities affecting newborns (approximately 1/1000 live births). Currently, the main treatment options for patients with hereditary hearing...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Affected persons with autosomal dominant hereditary sensorineural hearing loss, preferably confirmed by prior genetic testing
- Affected family members of enrolled participants with known autosomal dominant hereditary hearing loss
- Unaffected Family Members (Healthy Volunteers) of enrolled participant
- Adults must be able to provide informed consent
- Minors must have a parent or guardian able to provide informed consent
- Subjects must be 3-99 years of age
- EXCLUSION CRITERIA:
- Persons with sensorineural hearing loss (SNHL) and/or peripheral vestibular dysfunction associated with a non-genetic etiology such as infection, metabolic or immunologic disorders, or exposure to ototoxic agents such as cisplatin, or aminoglycoside antibiotics will not be included in this protocol.
- Persons with sensorineural hearing loss known to be associated with surgical intervention (e.g. acoustic neuroma removal, failed stapedectomy).
- Prospective study subjects who are cognitively impaired and lack consent capacity, will not be enrolled. The pre-screening eligibility checklist, which will be used and documented for registration under this protocol, is provided in a separate document.
Exclusion
Key Trial Info
Start Date :
February 9 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 21 2029
Estimated Enrollment :
1100 Patients enrolled
Trial Details
Trial ID
NCT04501081
Start Date
February 9 2021
End Date
August 21 2029
Last Update
December 24 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892