Status:
COMPLETED
Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:
Lead Sponsor:
The Cleveland Clinic
Conditions:
Cardiac Disease
Eligibility:
All Genders
19+ years
Phase:
PHASE3
Brief Summary
The relative increase in the mPAP with the same unit increase in MAP adjusted for baseline, and RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pr...
Detailed Description
The specific aims of our study are to compare 1) the relative increase in the mPAP with the same unit increase in MAP adjusted for baseline and 2) RV function assessed by GLS, between VP and NE in pat...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Adults\> 18 years of age
- Elective cardiac surgery with the use of CPB
- Patients with pulmonary artery catheter insertion
- Systemic hypotension (MAP \< 70 mmHg) requiring continuous infusion of vasopressor
- Exclusion Criteria:
- Transplant surgery
- Ventricular assist device implantation other than intra-aortic balloon counter-pulsation
- Pulmonary endarterectomy
- Thoracoabdominal aneurysm repair
- Inhalational pulmonary vasodilators (e.g. Epoprostenol) administration before insertion of pulmonary artery catheter
- Vasopressin is started as the first choice of pressor per clinical staff discretion
Exclusion
Key Trial Info
Start Date :
November 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
153 Patients enrolled
Trial Details
Trial ID
NCT04501861
Start Date
November 5 2020
End Date
December 31 2024
Last Update
March 24 2025
Active Locations (1)
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1
Cleveland Clinic
Cleveland, Ohio, United States, 44195