Status:
UNKNOWN
Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
ICU Patients
Healthy Lung
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
PEEP titration is a recommended during invasive mechanical ventilation of ICU patients. However, little is known about the right way to conduct this titration. PEEP titration can be conducted by a ste...
Detailed Description
Management of ICU patients may require the use of ventilatory support requiring tracheal intubation and invasive mechanical ventilation. Any mechanically ventilated patient is exposed to the formatio...
Eligibility Criteria
Inclusion
- Patient over 18 years of age
- ICU patients with healthy lungs or lungs with Acute Respiratory Distress Syndrome (according to Berlin criteria) under mechanically invasive controlled ventilation (intubation or tracheotomy) in the early phase of admission (\< 12h)
- Patient deeply sedated (BIS between 30 and 50) and possibly under neuromuscular blocking agents (TOF \< 2/4 at the orbicular) in case of inspiratory efforts
- Patient hemodynamically stable with an optimized volemia using a monitoring system (see protocol).
- Consent to participate
- Patient benefiting from a Social Security Insurance
Exclusion
- Refusal to participate to the proposed study
- Obese patient with BMI ≥ 35 kg.cm-2
- Significant hemodynamic instability defined as \> 20% increase in catecholamine doses during the last hour, despite optimization of blood volume according to a pre-established protocol
- Contraindication to the use of the electro-impedance tomography technique
- Thoracic lesions
- Chest bandages
- Pace-maker/Implantable defibrillator
- Contraindication to the performance of an alveolar recruitment maneuver
- Major Emphysema
Key Trial Info
Start Date :
September 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2021
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT04503876
Start Date
September 12 2019
End Date
October 31 2021
Last Update
August 25 2021
Active Locations (1)
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1
CHU
Clermont-Ferrand, France