Status:
RECRUITING
TCF-001 TRACK (Target Rare Cancer Knowledge) Study
Lead Sponsor:
TargetCancer Foundation
Collaborating Sponsors:
Foundation Medicine
Conditions:
Rare Cancers
Cholangiocarcinoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This open label, non-randomized, multi-center, pragmatic study aims to establish whether patients with rare tumors can benefit from matched molecular therapy as dictated by their next-generation seque...
Detailed Description
This open label, non-randomized, multi-center, pragmatic study aims to establish whether patients with rare tumors can benefit from matched molecular therapy as dictated by their next-generation seque...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA
- Provision of signed and dated informed consent form.
- Stated willingness to comply with all study related blood draws and assessments for the duration of the study.
- Individuals who are 18 years old or older at the time of consent.
- Patients with a rare (fewer than 6 cases per 100,000 per year) solid tumor or lymphoma with evaluable disease at baseline. The complete list of included cancers are included in the study protocol; diseases not listed in the study protocol may be enrolled with the approval of the Principal Investigator.
- May or may not have had qualifying (by Foundation Medicine) comprehensive genomic profiling before the present study. For those who have had qualifying comprehensive genomic profiling performed prior to the present study, the archival specimen tested must have been harvested within 18 months of the baseline visit (i.e. date of consent) of the present study.
- Willingness to provide existing archived and/or newly collected tissue resulting from standard of care procedures and blood samples for genomic profiling. If the submitted sample is determined to be insufficient for testing, the patient will be considered to be a screen failure.
- For archival tissue to be used for comprehensive genomic profiling for the present study, that specimen must have been harvested within 18 months of the baseline visit (i.e. date of consent) of the present study.
- Willingness to provide clinical and medical information to the study team as required.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
- Ability to read, write and communicate in English.
- Ability to review and sign a web-based informed consent form, or review and sign an informed consent form in treating physician office.
- Resides within the United States.
- EXCLUSION CRITERIA
- Participants who are unable to provide informed consent.
- Participants who are 17 years of age or younger.
- Participants who are unable to comply with the study procedures.
- Known existence of an uncontrolled intercurrent illness including, but not limited to, psychiatric illness or social situations that would impair compliance with study requirements.
- Concurrent active malignancy requiring treatment within 1 year of enrollment, at the discretion of treating physician.
- Pregnancy or breastfeeding.
- Any unlisted criteria at the discretion of the treating physician.
Exclusion
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04504604
Start Date
October 1 2020
End Date
December 1 2025
Last Update
August 9 2024
Active Locations (1)
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1
TargetCancer Foundation
Cambridge, Massachusetts, United States, 02139