Status:
RECRUITING
Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy
Lead Sponsor:
Institut Paoli-Calmettes
Conditions:
Breast Cancer Female
Eligibility:
FEMALE
18+ years
Brief Summary
The present project aims at identifying robust candidates for drug resistance in BC patients eligible for NAC. Its originality lies upon the combination of three different and complementary prospectiv...
Detailed Description
Breast cancer (BC) is a major public health problem in France, with an increasing incidence, estimated at \~60,000 new cases in 2017 and 12,000 deaths. Despite survival improvement in the recent years...
Eligibility Criteria
Inclusion
- Woman over 18
- Signed consent to participate
- Invasive mammary adenocarcinoma proven histologically and / or cytologically
- Indication of CNA retention by the referring clinical team.
- No contraindication to CNA.
- Selected indication of the post-CNA surgery sequence, then radiotherapy
- Performance index ≤ 1 (WHO).
- Affiliation to a social security scheme, or beneficiary of such a scheme
Exclusion
- Planned therapeutic sequence: CNA, followed by neoadjuvant radiotherapy (HIST-RIC clinical trial for example) before surgery
- Metastatic disease at diagnosis
- Patient relapsed from breast cancer precede
- Other malignant disease in the previous 3 years, with the exception of cervical carcinoma in situ or skin basal cell carcinoma and any other cancerous pathology considered to have been properly treated and at low risk of relapse.
- Woman pregnant or likely to be (without effective contraception) or breastfeeding
- Person in an emergency situation, adult person subject to a legal protection measure (adult under guardianship, guardianship or legal protection), or unable to express consent.
- Inability to undergo medical monitoring of the trial for geographical, social or psychological reasons
Key Trial Info
Start Date :
November 3 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2030
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04504747
Start Date
November 3 2022
End Date
January 1 2030
Last Update
June 15 2025
Active Locations (1)
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1
Institut Paoli-Calmettes
Marseille, Marseille, France, 13009