Status:
UNKNOWN
Low-dose Aspirin Therapy in Patients With Ischemic Stroke and Microbleeds
Lead Sponsor:
Xijing Hospital
Collaborating Sponsors:
Shaanxi Provincial People's Hospital
The First Affiliated Hospital of Jiaotong University
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to investigate the safety and efficacy of low-dose (50mg) aspirin as a secondary prevention drug in patients with Non-Cardioembolic Ischemic Stroke accompanied by cerebral...
Detailed Description
Cerebral microbleeds are caused by microvascular lesions in the brain, which is a subclinical deposition of hemosiderin after the damage of microvascular. Aspirin is the most widely used anti-thrombot...
Eligibility Criteria
Inclusion
- Patients with cerebral infarction diagnosed clinically as non-cardioembolic ischemic stroke;
- Age ≥ 18 years;
- Onset time ≤ 3 weeks;
- At least one cerebral microbleeds lesion was found on SWI;
- Informed consent was signed.
Exclusion
- Patients with symptomatic intracranial hemorrhage;
- No microbleeds or bleeding lesion \> 10 mm was found on SWI;
- Vascular malformations, tumors, abscesses or other major non ischemic brain diseases were present;
- Clear anticoagulant indications (such as atrial fibrillation);
- There are contraindications for aspirin use;
- The focus of microbleeds is limited to the cortex or other evidence suggests that the patient has cerebral amyloid angiopathy;
- Patients with coronary heart disease or other diseases need to take antiplatelet drugs;
- Serious systemic diseases;
- Refusal to sign informed consent or poor compliance.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2022
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04504864
Start Date
October 1 2020
End Date
August 1 2022
Last Update
February 9 2022
Active Locations (6)
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1
Baoji Central Hospital
Baoji, Shaanxi, China
2
Department of Neurology, Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032
3
Tangdu Hospital
Xi'an, Shaanxi, China, 710038
4
The First Affiliated Hospital of Xi'an Medical University
Xi'an, Shaanxi, China