Status:
COMPLETED
Is Self-transfusion Safe After Total Knee Arthroplasty in Terms of Nephrotoxicity of Gentamicin From Bone Cement?
Lead Sponsor:
University Hospital, Alexandroupolis
Collaborating Sponsors:
Democritus University of Thrace
Conditions:
Arthroplasty Complications
Total Knee Arthroplasty
Eligibility:
All Genders
Phase:
NA
Brief Summary
Considering that the high local concentration of antibiotic from bone cement is delivered intravenously through the self-transfusion process, systematic toxicity has never been evaluated. In addition,...
Eligibility Criteria
Inclusion
- end-stage of knee osteoarthritis, who scheduled for unilateral primary TKA in our department
Exclusion
- patients who had been treated with gentamicin within the past 10 days
- known allergies against the bone cement
- estimated glomerular filtration rate (eGFR) \<30ml/minute
- previous nephrectomy and history of renal transplant
- contraindications against tranexamic acid
Key Trial Info
Start Date :
January 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04505748
Start Date
January 1 2020
End Date
August 1 2020
Last Update
August 10 2020
Active Locations (1)
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1
University General Hospital of Alexandroupolis
Alexandroupoli, Evros, Greece, 68100