Status:
WITHDRAWN
Perioperative Vitamin C Lung Transplant
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Primary Graft Dysfunction
Lung Transplant; Complications
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
This study is being done to determine if parenterally administered ascorbic acid (Vitamin C) given at the time of lung transplant is safe. Vitamin C may be an effective intervention towards primary gr...
Detailed Description
PGD is a frequent and severe outcome that impacts both short- and long-term outcomes after lung transplantation. Major pathophysiologic contributors include ischemia and reperfusion injury, mitochondr...
Eligibility Criteria
Inclusion
- Participant is scheduled for lung transplantation
Exclusion
- Non-English speaking
- Subject is known or believed to be pregnant
- Subject is a prisoner.
- Subject has impaired decision-making capacity.
- Subject has known allergy to vitamin C.
- Subject has history of nephrolithiasis, oxalosis or hyperoxaluria. (Cystic Fibrosis patients are at risk of occult oxalosis / hyperoxaluria, therefore they will also be excluded from the study.)
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Sickle cell anemia
- Heredity hemochromatosis
- Baseline creatinine \>2 mg/dL or any current kidney injury
- Weight \<60 kg
- Vitamin C supplement use or administration (including HAT therapy) within the last month prior to transplantation
- Current enrolment in another research study
- Not suitable for study participation due to other reasons at the discretion of the investigators.
Key Trial Info
Start Date :
April 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04505878
Start Date
April 1 2023
End Date
December 1 2023
Last Update
May 1 2023
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