Status:
COMPLETED
Predicting Placental Pathologies by Ultrasound Imaging
Lead Sponsor:
Mayo Clinic
Conditions:
Intrauterine Growth Restriction
Villitis
Eligibility:
FEMALE
18-45 years
Brief Summary
Intrauterine growth restriction (IUGR) is caused when the placenta cannot provide enough nutrients to allow normal growth of the fetus during pregnancy. It is unclear why IUGR happens, but an increase...
Detailed Description
Intrauterine growth restriction (IUGR) occurs in 3-10% of all pregnancies and is associated with significant morbidity and mortality during pregnancy, after birth and throughout the child's lifespan. ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for IUGR study cohort:
- Pregnancy \> 28 weeks gestation
- Diagnosis of Intrauterine Growth Restriction (IUGR) before admission for labor and delivery
- Weight \> 110 lbs (50 kg)
- Ability to understand and provide written informed consent
- Inclusion Criteria for control cohort:
- Pregnancy \> 28 weeks gestation
- No known pregnancy complications at prenatal obstetrical visit (+/- 1 week gestational age of matched subject in IUGR cohort)
- Weight \> 110 lbs (50 kg)
- Ability to understand and provide written informed consent
- Exclusion Criteria:
- Known immunodeficiency or pregnancy complication (i.e. preeclampsia or gestational diabetes)
- Known autoimmune disease (e.g., rheumatoid arthritis or systemic lupus erythematosus) or chronic hypertension
- Chronic, active viral infections, including HIV-1/2, HTLV-1/2, Hepatitis B or C
- Solid organ or transplant recipient
- Current smokers (tobacco exposure within 30 days of registration)
- Conceptions from assisted reproductive technology (prior Clomid use is allowed)
- Multiple gestation
- Ruptured membranes
- Pregnancy \<28 weeks gestation
- Not planning on delivering at Mayo Clinic
Exclusion
Key Trial Info
Start Date :
September 27 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04506970
Start Date
September 27 2020
End Date
October 31 2023
Last Update
October 10 2024
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905