Status:
COMPLETED
High Flow Nasal Cannula With Noninvasive Ventilation
Lead Sponsor:
University of Oklahoma
Conditions:
Acute Respiratory Failure
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
This is a prospective, randomized, unblinded trial of trauma patients in the ICU who are identified as being at a high risk to develop acute respiratory failure. We hope that this study will help the...
Detailed Description
All patients consented will be randomly assigned into one of three groups: nasal cannula (control group, our current standard of care), high-flow nasal cannula, high-flow nasal cannula plus noninvasiv...
Eligibility Criteria
Inclusion
- Adults at least 18 years of age
- Admission to an intensive care unit by the trauma surgery service
- Trauma patients receiving any respiratory therapies
- High risk patients, including intubation, post-operative, chronic cardiac or pulmonary comorbidities
- Thoracic injuries, including rib fractures, sternal fractures, spinal fractures, pulmonary contusions, pneumothorax, hemothorax, diaphragm injury
- Postoperative from thoracic surgery
- Postoperative from spine surgery in patients without spinal cord injury
- Abdominal injuries requiring open abdominal surgery
- No contraindications to using high flow nasal cannula or noninvasive ventilation
Exclusion
- Contraindication to using high flow nasal cannula or noninvasive ventilation
- Intolerance of pulmonary therapies
- No one able to give informed consent
- Long-term treatment with noninvasive ventilation prior to hospital admission
- "Do not intubate" order at time of extubation
- Unplanned extubation (accidental or self-extubation)
- Age \< 18 years of age
- Traumatic brain injury with GCS \< 8
- Spinal cord injury
- Chronic neuromuscular disease
- Sinus precautions due to facial/sinus fractures
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 10 2023
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT04507425
Start Date
September 1 2020
End Date
July 10 2023
Last Update
November 21 2023
Active Locations (1)
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1
OU Medical Center
Oklahoma City, Oklahoma, United States, 73104