Status:
COMPLETED
Universal Familial Hypercholesterolemia Screening in Children
Lead Sponsor:
University of Ljubljana, Faculty of Medicine
Collaborating Sponsors:
University Medical Centre Ljubljana
Kinderkrankenhaus auf der Bult
Conditions:
Familial Hypercholesterolemia
Polygenic Hypercholesterolaemia
Eligibility:
All Genders
Brief Summary
30 million individuals globally with undiagnosed familial hypercholesterolemia (FH) are at a substantial cardiovascular disease (CVD) risk, which could be normalized by early diagnosis and treatment. ...
Detailed Description
The study will include pediatric patients (or their siblings and parents in Slovenian cohort) undergoing the universal hypercholesterolemia screening; those with elevated cholesterol at universal chol...
Eligibility Criteria
Inclusion
- Elevated total cholesterol (cohort 1) or LDL-cholesterol (cohort 2) at universal screening program in children.
- Completed FH genetic analysis (cohort 3).
- Parent or sibling of child with confirmed familial hypercholesterolemia (cohort 4).
Exclusion
- Children with hypercholesterolemia not referred through the screening program.
- FH genetic analysis not completed.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
17000 Patients enrolled
Trial Details
Trial ID
NCT04507984
Start Date
January 1 2019
End Date
December 31 2021
Last Update
May 18 2023
Active Locations (2)
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1
Children's Hospital AUF DER BULT
Hanover, Germany, 30173
2
UMC - University Children's Hospital Ljubljana
Ljubljana, Slovenia, 1000