Status:
COMPLETED
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Lead Sponsor:
Northern State Medical University
Conditions:
ARDS, Human
Sepsis, Severe
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective...
Detailed Description
In all patients, investigators catheterized the internal jugular or the subclavian vein with a triple-lumen central venous catheter (Certofix, B\|Braun, Germany) and the femoral artery with a thermist...
Eligibility Criteria
Inclusion
- The presence of sepsis ( the third international definition of sepsis and septic shock )
- The precence of ARDS (the Berlin definition of ARDS)
- mechanical ventilation before the study for at least 24 hrs
- the age of the patient \> 18 years.
Exclusion
- continuous infusion of norepinephrine in a dose exceeding 0.4 mcg/kg/min to maintain mean arterial pressure (MAP) within 65-75 mm Hg,
- morbid obesity with BMI \> 40 kg/m2,
- severe brain injury,
- chronic kidney diseases,
- pregnancy,
- known irreversible underlying conditions such as end-stage neoplasms.
Key Trial Info
Start Date :
March 10 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 10 2020
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04508296
Start Date
March 10 2016
End Date
December 10 2020
Last Update
March 22 2024
Active Locations (1)
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1
City Hospital # 1 n.a. E.E. Volosevich
Arkhangelsk, Russia, 163000