Status:
COMPLETED
Liver Glycogen Dynamics
Lead Sponsor:
Maastricht University
Conditions:
Hepatic Glycogen
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the effect of prolonged overnight fasting in the hepatic glycogen stores
Eligibility Criteria
Inclusion
- Participants are able to provide signed and dated written informed consent prior to any study specific procedures
- Caucasian (people will be excluded when having a ≥50% racial African/Asian background)
- Participants should have suitable veins for cannulation or repeated venipuncture
- Women are post-menopausal (defined as at least 1 year post cessation of menses)
- Men and women aged ≥ 45 and ≤ 75 years at the start of the study
- Body mass index (BMI) 18.5 - 25 kg/m2
- Stable dietary habits (no weight loss or gain \>3kg in the past 3 months)
- Sedentary lifestyle (not more than 3 hours of vigorous sports per week)
Exclusion
- Type 2 Diabetes Mellitus
- Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
- Any contraindication for MRI scanning
- Alcohol consumption of \>2 servings per day
- Regular smoking
- No use of medication interfering with investigated study parameters (as determined by responsible physician)
- Participants who do not want to be informed about unexpected medical findings, or do not wish that their physician
Key Trial Info
Start Date :
September 11 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 21 2021
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04510155
Start Date
September 11 2020
End Date
May 21 2021
Last Update
June 2 2021
Active Locations (1)
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1
Maastricht University
Maastricht, Limburg, Netherlands, 6229ER