Status:
COMPLETED
Imaging Properties of PET Radiotracer [18F]3F-PHPG in Patients With Neuroendocrine Tumors
Lead Sponsor:
University of Michigan Rogel Cancer Center
Conditions:
Neuroendocrine Tumors
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
The goal of this exploratory study is to test whether \[18F\]3F-PHPG can be used reliably to map the locations of tumors in patients with neuroendocrine tumors. If so, the results of this study will b...
Detailed Description
Subjects enrolled in this study will be recruited from the population of adult patients with neuroendocrine tumors, including pheochromocytoma and paraganglioma, being treated at the University of Mic...
Eligibility Criteria
Inclusion
- Current neuroendocrine tumor diagnosis
- Able to lie flat for 60 minutes
- Provision of informed consent
Exclusion
- Pregnancy or lactation
- Claustrophobia
- Inability to lie flat for 60 minutes
- Currently taking medications that may alter PET scans of neuroendocrine tumors with these tracers, including any of the following:
- Tricyclic antidepressants, which inhibit the norepinephrine transporter: desipramine, amitriptyline, imipramine
- Cold medications containing the sympathomimetic amines: phenylephrine, phenylpropanolamine, pseudoephedrine
- Nasal decongestants (some use phenylephrine as the active agent)
- Cocaine (which inhibits the norepinephrine transporter)
- Tetrabenazine (Xenazine), which inhibits the VMAT2 transporter
- Monoamine oxidase inhibitors (MAOI)
- Some antihypertensive drugs: reserpine, labetalol, α-methyldopa, clonidine
Key Trial Info
Start Date :
October 19 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT04510311
Start Date
October 19 2020
End Date
December 31 2024
Last Update
January 10 2025
Active Locations (1)
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1
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48109