Status:
COMPLETED
Characterization of New Human Models of Non-histaminergic Itch
Lead Sponsor:
Aalborg University
Conditions:
Papain
Itch
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
In this experiment the investigators would like to test a new new human itch model based on papain, and to characterize the sensory quality and temporary aspects of papain skin prick test (SPT) in com...
Detailed Description
The most used model of non-histaminergic itch is cowhage but this models presents several problems, such us the impossibility of standardizing the amount of the spicules inserted in the skin and the d...
Eligibility Criteria
Inclusion
- Healthy men and women
- 18-60 years
- Speak and understand English
Exclusion
- Pregnancy or lactation
- Drug addiction defined as any use of cannabis, opioids or other addictive drugs
- Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.).
- Lack of ability to cooperate
- Current use of medications that may affect the trial such as antihistamines, antipsychotics and pain killers, as well as systemic or topical steroids.
- Skin diseases
- Moles, scars or tattoos in the area to be treated or tested.
- Hypersensitivity to papaya and mango fruit, cashew nuts, rubber latex
- Consumption of alcohol or painkillers 24 hours before the study days and between these
- Acute or chronic pain
- Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04515056
Start Date
September 1 2020
End Date
June 1 2021
Last Update
July 9 2021
Active Locations (1)
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1
Aalborg University
Aalborg, North Denmark, Denmark, 9000