Status:
COMPLETED
Plantarflexor PAS - Stroke
Lead Sponsor:
VA Office of Research and Development
Conditions:
Stroke
Hemiparesis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The current project investigates a method called paired associative stimulation (PAS) which is known to influence nervous system function through a process called neuroplasticity. Here the investigato...
Detailed Description
The current project builds on preliminary work in which the investigators have observed a relationship between efficacy of the corticospinal tract serving the plantarflexors and walking function, spec...
Eligibility Criteria
Inclusion
- hemiparesis resulting from stroke
- single, unilateral, hemispheric stroke (cortical or sub-cortical areas)
- stroke confirmed by neuroimaging (CT or MRI)
- stroke 3 months prior to enrollment
- ability to walk, independently at least 25' on level ground, even if requiring brace or assistive device (cane)
- Veteran Status prioritized
Exclusion
- lower extremity pain affecting ability to bear weight on legs
- contractures limiting normal range of motion in major lower extremity joints
- other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS), prior traumatic brain injury, severe osteoarthritis or prior pathological fracture
- cardiovascular conditions contraindicative to walking or light exercise
- severe hypertension (i.e., \>200/110 at rest that cannot be controlled in resting range of 180/110 mmHg)
- perceptual or cognitive deficits affecting ability to: comprehend, follow three step directions, or provide consent
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04515407
Start Date
October 1 2021
End Date
September 30 2023
Last Update
February 22 2024
Active Locations (1)
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1
Martinez Outpatient Clinic and Community Living Center, Martinez, CA
Martinez, California, United States, 94553