Status:
UNKNOWN
The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury
Lead Sponsor:
University Medical Centre Ljubljana
Conditions:
Brain Injuries, Traumatic
Coagulopathy
Eligibility:
All Genders
18-80 years
Brief Summary
Aim of the study The investigators aim to establish: * Whether noradrenaline (NA) infusion has a significant effect on coagulation and fibrinolysis in patients with severe traumatic brain injury (TB...
Detailed Description
STUDY DESIGN AND METHODS The research shall be carried out at the Department of Anaesthetics and Surgical Intensive Care/Intensive Care Unit (ICU) at the University Medical Centre Ljubljana and will b...
Eligibility Criteria
Inclusion
- patients with traumatic brain injury
- Glasgow Coma Scale ≤ 8
- Head Abbreviated Injury Scale (AIS) ≥ 3
Exclusion
- patients with any kind of extracranial injury
- patients receiving anticoagulation or anti aggregation therapy
- patients with a known neurological disorders
- patients with haematological disorders
- patients with malign diseases
- patients with liver disease
- patients with any infection
- patients after cardiac arrest
- patients after craniotomy
- patients that have received transfusion of contentrated erythrocytes and/or fresh frozen plasma
- patients that have received thrombocyte plasma
- body temperature \<35°C
- pregnant women
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04515420
Start Date
September 1 2020
End Date
September 1 2022
Last Update
August 17 2020
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