Status:
COMPLETED
Shivering and Glucose Homeostasis
Lead Sponsor:
Maastricht University
Conditions:
Healthy Overweight/Obese
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the effect of prolonged shivering thermogenesis on glucose homeostasis in overweight/obese humans.
Eligibility Criteria
Inclusion
- Signed informed consent
- Caucasian
- Healthy (as determined by dependent physician based on medical questionnaire)
- Man, or postmenopausal (defined as at least 1year post cessation of menses) woman
- Aged 40 - 75 years at the start of the study
- BMI 27 and 35 kg/m2
- Stable dietary habits (no weight loss or gain \>3kg in the past 3 months)
Exclusion
- \- Not meeting all inclusion criteria
- Medication use known to hamper subject's safety during study procedures
- Co-morbidities to which the intervention or program that may pose as a complicating factor
- Subjects diagnosed with cardiovascular diseases or cancer
- Fasting plasma glucose ≥ 7.0 mmol/l
- Haemoglobin \< 7.8 mmol/l for women, or \< 8.4 mmol/l for men
- Previously diagnosed with type 2 diabetes
- Abuse alcohol/drug abuse
- Subjects who do not want to be informed about unexpected medical findings during the screening/study or do not wish that their physician is informed.
- Engagement in structured exercise \> 2h per week
- Participation in another biomedical study within 1 month before the first study
- Smoking
- Cold-acclimated, such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 13 2021
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04516018
Start Date
September 1 2020
End Date
December 13 2021
Last Update
January 14 2022
Active Locations (1)
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1
Maastricht University
Maastricht, Limburg, Netherlands, 6229ER