Status:
ACTIVE_NOT_RECRUITING
Neurofilament Surveillance Project (NSP)
Lead Sponsor:
The Bluefield Project to Cure Frontotemporal Dementia
Collaborating Sponsors:
Mayo Clinic
University of California, San Francisco
Conditions:
Frontotemporal Dementia
Frontotemporal Lobar Degeneration
Eligibility:
All Genders
18-85 years
Brief Summary
This is a biomarker study designed to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control group of i...
Detailed Description
Frontotemporal Lobar Degeneration (FTLD), a group of clinically heterogeneous neurodegenerative diseases characterized by progressive deterioration of the frontal and temporal cortices as well as basa...
Eligibility Criteria
Inclusion
- Male or female
- Ages 18-85
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Is enrolled in the longitudinal arm of ALLFTD
- Is a member of a family with a known mutation in C9orf72, GRN or MAPT
Exclusion
- Any permanent contra-indication to repeated blood draws, such as poor venous access.
- Any conditions or circumstances which, in the opinion of the investigator, would not allow participation in the study.
Key Trial Info
Start Date :
September 2 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2027
Estimated Enrollment :
342 Patients enrolled
Trial Details
Trial ID
NCT04516499
Start Date
September 2 2020
End Date
February 1 2027
Last Update
October 29 2025
Active Locations (8)
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1
University of California, San Francisco
San Francisco, California, United States, 94158
2
Mayo Clinic Florida
Jacksonville, Florida, United States, 32224
3
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21287
4
Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02129