Status:
RECRUITING
Longitudinal Neuroimaging in Sturge-Weber Syndrome
Lead Sponsor:
Wayne State University
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Sturge-Weber Syndrome
Eligibility:
All Genders
3-30 years
Phase:
NA
Brief Summary
In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging app...
Detailed Description
This project will combine advanced neuroimaging with detailed neuro-psychology evaluation, performed in both children and young adults affected by Sturge-Weber syndrome, in order to address two main a...
Eligibility Criteria
Inclusion
- Subjects with Sturge-Weber syndrome (SWS):
- Age 3 months - 30 years;
- Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.);
- In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language.
- Healthy control subjects:
- Age 3 years - 30 years;
- No history of neurological or psychiatric disorder
Exclusion
- For all subjects:
- Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning.
- History of severe claustrophobia, precluding staying still in the scanner for up to 30 minutes.
- Pregnancy (pregnant women will be scheduled for the study after delivery).
- For SWS subjects, who will receive MRI contrast material, additional exclusion criteria:
- History of sensitivity to MRI contrast material;
- History of renal disease that would preclude safe administration of MRI contrast material
Key Trial Info
Start Date :
March 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04517565
Start Date
March 1 2020
End Date
February 28 2026
Last Update
July 15 2025
Active Locations (1)
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1
Wayne State University / Children's Hospital of Michigan
Detroit, Michigan, United States, 48201