Status:
RECRUITING
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
Lead Sponsor:
University of Iowa
Conditions:
Asthma
Bone Density, Low
Eligibility:
All Genders
25-45 years
Brief Summary
The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patient...
Detailed Description
This study aims to prove that emerging CT-based tools are suitable to measure changes in central and peripheral bone density, geometry, micro-structure, and marrow adipose tissue (MAT) among patients ...
Eligibility Criteria
Inclusion
- Inclusion (all subjects):
- Diagnosis of severe, persistent asthma (defined as using both a long-acting beta-agonist AND a high-dose inhaled steroid)
- Age 25-45
- Inclusion (oral steroid group):
- Chronic treatment with oral steroids for at least 45 days but less than 1 year
Exclusion
- Exclusion (all subjects):
- Pregnant or breastfeeding
- History of any cancer, excluding non-melanoma skin cancer
- Currently receiving dialysis
- History of any lower extremity fracture
- Hip or knee replacement
- Non-ambulatory
- Greater than 10 pack-year smoking history
- BMI \> 50
- Age \< 25 or \> 45
- Current or past use of FDA-approved medication for osteoporosis:
- Bisphosphonates (Alendronate/Fosamax, Ibandronate/Boniva, Risedronate/Actonel/Atelvia, Zoledronic Acid/Reclast) Calcitonin (Fortical, Miacalcin) Selective Estrogen Receptor Modulator (Raloxifene/Evista) Parathyroid Hormone Analogue (Teriparatide/Forteo) Monoclonal Antibody (Denosumab/Prolia)
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04518722
Start Date
December 1 2020
End Date
January 1 2026
Last Update
January 9 2026
Active Locations (1)
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1
University of Iowa
Iowa City, Iowa, United States, 52242