Status:
UNKNOWN
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Lead Sponsor:
Tang-Du Hospital
Conditions:
Fertilization
Eligibility:
FEMALE
22-50 years
Phase:
NA
Brief Summary
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its...
Detailed Description
The ICSI procedure improves fertilization rates in cases of male factor infertility. However, fertilization failure still occurs in 1-5% in ICSI cycles. The main cause of failed fertilization is failu...
Eligibility Criteria
Inclusion
- The patients suffered at least one complete fertilization failure or low fertilization rate after performing standard ICSI in previous cycle. Low fertilization was defined as less than 33% fertilization rate.
- The patients suffered at least 2 cycles complete fertilization failure or low fertilization rate after performing IVF in previous cycle. Low fertilization was defined as less than 33% fertilization rate.
- The sperm of the patients has the following characteristics: globozoospermia, acrosomal deletion or small, severe head deformity, etc.
- Sperm of testicular origin and/or sperm that has been freeze-thawed.
- The sperm was PLC-ζ missing.
- The MII oocytes were IVM cultured and/or freeze-thawed.
- The patients suffered at least 2 cycles no available embryos, because of the embryo development block or fragmentation.
Exclusion
- Normal fertilization IVF/ICSI cycles.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2022
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04519918
Start Date
October 1 2020
End Date
August 31 2022
Last Update
September 1 2020
Active Locations (1)
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1
Tangdu Hospital
Xi'an, Shaanxi, China, 710038