Status:
COMPLETED
Ventilator-associated Injury (VAI) in Chronic Home Mechanical Ventilation
Lead Sponsor:
University Medical Center Groningen
Conditions:
Respiratory Failure
Long-term Non-invasive Ventilation
Eligibility:
All Genders
18+ years
Brief Summary
Rationale: The pathophysiological changes in respiratory muscle morphology and functioning in patients with end-stage pulmonary disease are not very well known. Furthermore, in COPD, long-term high-i...
Detailed Description
Rationale: Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory disease characterised by airway and lung parenchyma damage. At end-stage disease patients may develop chronic hyp...
Eligibility Criteria
Inclusion
- RLD: probable or confirmed diagnosis of interstitial pulmonary fibrosis (IPF) or other fibrotic lung disease of unknown origin.
- COPD: GOLD stage III or IV
- Being listed for lung transplantation
Exclusion
- Concomitant neuromuscular or systemic/collagen-vascular disease
- Prior lung surgery (except for lung biopsies) or lung volume reduction treatment
- Being unable to understand the patient information and consent for the study
Key Trial Info
Start Date :
October 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2023
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04521426
Start Date
October 1 2020
End Date
September 1 2023
Last Update
November 29 2023
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands