Status:
UNKNOWN
A Trial of Adjuvant Therapy After Hepatocarcinoma Resection Based on Folate Receptor-positive Circulating Tumor Cells
Lead Sponsor:
Eastern Hepatobiliary Surgery Hospital
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The aim of this study is to analyze the therapeutic effect of postoperative adjuvant chemotherapy with FOLFOX4 after hepatocarcinoma resection based on folate receptor-positive circulating tumor cells...
Detailed Description
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death globally. Hepatectomy remains the most widely practiced radical treatment for HCC despite having a high associated recurrence ...
Eligibility Criteria
Inclusion
- Patients with HCC who received curative liver resection (R0);
- Karnofsky Performance Score performance over 60;
- The functions of the kidney, heart and lung and the blood system are normal and fittable for Licardin therapy;
- The liver function is of grade A or B in Child-Pugh classification;
- Patients agreed to collect peripheral blood for detection of CTC at the designated time point;
- Patients should sign the informed consent of this study.
Exclusion
- If postoperative liver function is Child C, it cannot tolerate chemotherapy;
- Blood transfusion history within 1 month before enrollment;
- Severe gastroesophagealvarices with red sign or with variceal hemorrhage before;
- Malignant or metastatic tumor in other sites in last 5 years;
- Patients can not be followed-up regularly;
- Patients participating in other trials or received other treatment previously.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
184 Patients enrolled
Trial Details
Trial ID
NCT04521491
Start Date
December 1 2020
End Date
December 31 2023
Last Update
August 20 2020
Active Locations (1)
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1
Eastern hepatobilliary surgery hospital
Shanghai, Shanghai Municipality, China, 200438