Status:
UNKNOWN
Prolonged Protocol of Early Follicular or Mid Luteal Phase
Lead Sponsor:
Second Affiliated Hospital of Wenzhou Medical University
Conditions:
IVF
Eligibility:
FEMALE
18-42 years
Phase:
NA
Brief Summary
Due to the injection of gonadotropin releasing hormone agonist (GnRH-a) before controlled ovarian hyperstimulation (COH), the scheme of prolonged early follicular period protocol has obvious advantage...
Detailed Description
One injection of 3.75mg GnRHa was injected on the 1st-3rd or 21st-23rd day of menstruation. The level of estradiol (E2), progesterone (P), luteinizing hormone (LH) in peripheral blood and the number o...
Eligibility Criteria
Inclusion
- Tubal factor infertility;
- polycystic ovary (PCO) or polycystic ovary syndrome (PCOS) patients;
- Patients of mild to moderate endometriosis；
- Oligoasthenospermia in male；
- More than 5 antral follicle count (AFC) on both ovaries；
- Unexplained infertility: there is a history of no contraception and pregnancy for more than 1 year, no clear cause of infertility such as ovulation, fallopian tube, endometrium and male factors is found, or the above factors return to normal after treatment.
Exclusion
- History of adverse pregnancy and childbirth；
- Unilateral ovariectomy；
- Uterine malformation, intrauterine adhesion, submucous myoma；
- Chromosomal abnormality of both husband and wife；
- Patients with contraindications of assisted reproductive technology or pregnancy: such as uncontrolled diabetes mellitus, undiagnosed liver and kidney dysfunction, history of deep vein thrombosis, history of pulmonary embolism, history of cerebrovascular accident, uncontrolled hypertension, heart disease, suspected cervical cancer, endometrial cancer, breast cancer or previous history, undetermined vaginal bleeding;
- Unable to be regularly follow up；
- Participating in other clinical trials；
- No fresh single blastocyst transfer.
Key Trial Info
Start Date :
May 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 13 2024
Estimated Enrollment :
1150 Patients enrolled
Trial Details
Trial ID
NCT04522479
Start Date
May 13 2020
End Date
May 13 2024
Last Update
August 21 2020
Active Locations (1)
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1
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325027