Status:
COMPLETED
Human Intestinal Amino Acid Absorption and the Role of a Local RAS
Lead Sponsor:
University Children's Hospital Basel
Conditions:
Renin-Angiotensin Aldosterone System (RAS)
Eligibility:
All Genders
18-80 years
Brief Summary
This study is to find out what role a local intestinal RAS (renin angiotensin system) plays in the context of amino acid absorption in the human intestinal tract and how this RAS and thus the amino ac...
Eligibility Criteria
Inclusion
- Body Mass Index (BMI): 18-35 kg/m2
- cohort 1: therapy with an angiotensin II AT1 antagonist or ACE Inhibitor
- cohort 2: no therapy with an angiotensin II AT1 antagonist or ACE Inhibitor
- Carrying out a diagnostic gastroscopy, colonoscopy or a combined gastroscopy / colonoscopy
- Existence of written consent after detailed information about the study
Exclusion
- Severe pathological changes in the gastrointestinal tract (e.g. sprue, stomach ulcers, malignancies); (reflux esophagitis and gastritis are not Exclusion criteria)
- History of gastrointestinal tract surgery (except for appendectomy and inguinal hernia surgery)
- History of malignancy
- Severe acute and chronic organ diseases requiring treatment (e.g. kidney replacement therapy)
- Patients with an increased risk of bleeding (e.g. oral anticoagulation, coagulation disorders)
- Drug or alcohol abuse
- Mental impairment limiting the ability to meet all study requirements
Key Trial Info
Start Date :
January 27 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2011
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04524494
Start Date
January 27 2010
End Date
May 31 2011
Last Update
August 24 2020
Active Locations (2)
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1
Universitäts-Kinderspital beider Basel (UKBB)
Basel, Switzerland, 4031
2
UniversitätsSpital Zürich
Zurich, Switzerland, 8091