Status:
RECRUITING
Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
Lead Sponsor:
University Health Network, Toronto
Conditions:
Respiratory Insufficiency
Neuromuscular Blockade
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxe...
Detailed Description
Controlling respiratory effort in patients with AHRF can be challenging, as they often exhibit a very high respiratory drive despite receiving high doses of sedatives. Consequently, these patients usu...
Eligibility Criteria
Inclusion
- Patients supported on invasive mechanical ventilation for moderate to severe AHRF (PaO2/FiO2 \< 150 mm Hg or FiO2 ≥ 60% with an SpO2 ≤ 97% or receiving venovenous extracorporeal membrane oxygenation)
Exclusion
- Contraindication to neuromuscular blockade (allergy, history of malignant hyperthermia)
- Contraindication to ulnar nerve stimulation (bilateral peripheral neuropathy, skin burns on both wrists)
- Previous history of a formally diagnosed neuromuscular disorder
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT04524585
Start Date
October 1 2020
End Date
March 1 2027
Last Update
January 6 2026
Active Locations (1)
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1
University Health Network
Toronto, Ontario, Canada, M5G 2N2