Status:
TERMINATED
A Pilot Study to Characterise Saliva and Sputum FTIR Spectral Profiles in Patients with COPD During Exacerbations and When Stable
Lead Sponsor:
Portsmouth Hospitals NHS Trust
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40+ years
Brief Summary
This study will characterise saliva and sputum FTIR spectral profiles in patients with COPD, during exacerbations and stable disease.
Detailed Description
Chronic Obstructive Pulmonary Disease (COPD) is a common and treatable condition that is characterised by predominately irreversible and progressive airflow limitation. COPD is a leading cause of morb...
Eligibility Criteria
Inclusion
- Participants with a confirmed diagnosis of an exacerbation of COPD (aged ≥40 years), n=40 (20 participants recruited in phase 1 and 20 participants recruited in phase 2) who are able to spontaneously expectorates sputum during exacerbations and on at least 3 out of 7 days when well.
- Able to provide written informed consent
Exclusion
- Participants with other significant respiratory disease that, in the opinion of the clinical investigator, is the major cause of their respiratory symptoms (e.g. pulmonary tuberculosis, allergic bronchopulmonary aspergillosis, pulmonary fibrosis).
- Participants with COPD whose deterioration in respiratory symptoms is not thought to be due to an exacerbation of their COPD (e.g. pneumonia\*, pneumothorax, pulmonary embolus).
- A member of the research study medical team will review the participant's chest X-Ray (CXR) to exclude any pneumonia, defined by consolidation on CXR before they are recruited onto the study if a CXR has been taken. In participants who have not had a CXR, exclusion of pneumonia will be based on clinical assessment.
Key Trial Info
Start Date :
September 18 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2023
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04524819
Start Date
September 18 2019
End Date
October 31 2023
Last Update
November 8 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital
Portsmouth, Hampshire, United Kingdom, PO6 3LY