Status:
COMPLETED
Online Hemodiafiltration vs Conventional Hemodialysis in Acute Kidney Injury
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Only limited data exist on the benefit of online hemodiafiltration in patient with Acute kidney injury. The objective of this pilot RCT is to assess the feasibility of a large multicentre RCT to deter...
Detailed Description
Despite sparse data on the advantages of hemodiafiltration over conventional hemodialysis for intermittent dialysis, there is limited data comparing these modalities in AKI from various aetiologies in...
Eligibility Criteria
Inclusion
- Hospitalised in the ICU
- Acute kidney injury stage 3 (KDIGO-AKI Criteria)
- Requiring RRT for AKI, as judged by the attending clinician (initiation) or conversion from CRRT to intermittent dialysis
- Adult of 18 years or more
Exclusion
- Female subjects who are pregnant or breast-feeding or considering becoming pregnant during the study.
- Subjects who are participating in another study involving dialysis interventions
- Subjects or relatives/next-of-kin unable to provide written informed consent
- Creatinine clearance (CrCl) \< 30 mL/min measured by 24-hour urine collection or eGFR or on chronic dialysis at baseline
- Subjects on active immunosuppressive therapy (\>10mg of prednisone, biologic therapies, calcineurin inhibitors, mTOR inhibitors or antimetabolites)
- Subjects with active contraindication to anticoagulation during dialysis session
- Subjects whose RRT is not part of their life goal
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2024
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT04525092
Start Date
January 1 2021
End Date
December 1 2024
Last Update
February 18 2025
Active Locations (2)
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1
Centre de recherche du CHUM
Montreal, Quebec, Canada, H2X 0C1
2
Clinical Research Centre University College Dublin
Dublin, Ireland