Status:
UNKNOWN
Hand Sanitizer Effects on the Skin Barrier
Lead Sponsor:
National Jewish Health
Conditions:
Dermatitis Hand
Skin Abnormalities
Eligibility:
All Genders
18-60 years
Brief Summary
Hand washing and the use of hand sanitizers are important interventions in disease prevention. Engaging in frequent hand washing is especially effective in preventing the spread of viruses, as this re...
Detailed Description
Hand washing and the use of hand sanitizers are important interventions in disease prevention. Engaging in frequent hand washing is especially effective in preventing the spread of viruses, as this re...
Eligibility Criteria
Inclusion
- Inclusion criteria of the AD group:
- • Individuals with atopic dermatitis, ages 18-60 years old.
- Inclusion criteria of the non-atopic group, ages 18-60 years old:
- • Individuals with no history of atopic dermatitis, contact dermatitis, food allergy, asthma, or allergic rhinitis.
Exclusion
- Exclusion criteria of all subjects:
- Subject has taken systemic immunosuppressive drugs including oral steroids within 30 days of skin barrier assessment
- Subject has received immunotherapy in the past year
- Subject has received any biologic medications within 5 half-lives or 16 weeks, whichever is longer
- Subject has received any investigational drugs within 5 half-lives or 8 weeks, whichever is longer
- Subject has taken anti-anxiety, antidepressant, or anticoagulant medications in the last 30 days
- Subject has received total body phototherapy (e.g., ultraviolet light B \[UVB\], psoralen plus ultraviolet light A \[PUVA\], tanning beds \[\>1 visit per week\]) within 30 days of skin barrier assessment
- Subject has used topical corticosteroids, topical immunomodulatory agents, or topical antibiotics on the extremity being evaluated within 7 days of skin barrier assessment
- Subject has a severe concurrent disease or immunosuppression
- Subject has a history of a severe reaction to latex, tape, or adhesives
- Subject is pregnant or lactating
- For the medications below, they have to be temporarily withheld before participation in the study:
- If the subject is taking oral antihistamines, they will need to be withheld for five days prior to the skin barrier study.
- If the subject is taking oral antibiotics, antivirals, antifungals, or antiparasitics, the skin barrier studies can be scheduled seven days after the last dose has been taken.
- If the subject is taking topical medications including (but not restricted to) Elidel, Protopic, topical corticosteroids and topical antibiotics, they will need to be withheld on the hand being evaluated seven days prior to the skin barrier studies. Moisturizers will also need to be withheld on the area 24 hours prior to the visit. The subject cannot have taken a bleach bath within 7 days of the visit, and the subject cannot take a bath or shower on the day of the visit.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 20 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04525521
Start Date
December 1 2020
End Date
August 20 2021
Last Update
March 2 2021
Active Locations (1)
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1
National Jewish Health
Denver, Colorado, United States, 80206