Status:
COMPLETED
Influence of Aging on Perioperative Methadone Dosing
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Conditions:
Pain, Postoperative
Opioid Use
Eligibility:
All Genders
18-105 years
Phase:
PHASE4
Brief Summary
Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid for perioperative pain management, however, to date there are no pharmacokinetic or pharmacodynamic studies t...
Detailed Description
The subjects will be recruited from adult patients who undergo elective laparoscopic abdominal surgery at UC Christus Clinical Hospital (Santiago, de Chile). Patients will be randomly divided into fou...
Eligibility Criteria
Inclusion
- Over 18 years.
- ASA I, II or III.
- Laparoscopic Abdominal Surgery.
Exclusion
- BMI\> 35
- Use of opioids up to 5 days before surgery.
- Acute Liver Failure or Chronic Liver Damage Child C.
- Kidney damage with creatinine clearance estimated by Cockcroft-Gault formula \<60 ml/min.
Key Trial Info
Start Date :
September 3 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 13 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04526236
Start Date
September 3 2019
End Date
July 13 2022
Last Update
December 21 2023
Active Locations (1)
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1
Pontificia Universidad Católica de Chile
Santiago, Santiago Metropolitan, Chile, 8320000