Status:
COMPLETED
Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above
Lead Sponsor:
CanSino Biologics Inc.
Collaborating Sponsors:
Beijing Institute of Biotechnology
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This study is a global multicenter, randomized, double-blind, placebo -controlled, adaptive designed phase Ⅲ clinical trial, in order to evaluate the efficacy, safety and immunogenicity of Recombinant...
Detailed Description
This is a global phase III clinical trial to evaluate efficacy,safety, immuogenicity of Ad5-nCoV manufactured by Cansino and Beijing Institute of Biotechnology in health adults aged 18 years old and a...
Eligibility Criteria
Inclusion
- Adults of 18 years old and above.
- Participants who are at high risk of SARS-CoV-2 infection.
- Able and willing (in the Investigator's opinion) to comply with all study requirements.
- Willing to allow the investigators to discuss the volunteer's medical history with their General Practitioner/personal doctor and access all medical records when relevant to study procedures.
- Agreement to refrain from blood donation during the study.
- provide written informed consent.
Exclusion
- Participation in any other COVID-19 prophylactic drug trials for the duration of the study.
- Participation in SARS-CoV-2 serological surveys where participants are informed of their serostatus for the duration of the study.
- Planned receipt of any vaccine (licensed or investigational), other than the study intervention, within 14 days before and after study vaccination.
- Prior receipt of an investigational or licensed vaccine likely to impact on the interpretation of the trial data.
- Administration of immunoglobulins and/or any blood products within the three months prior to the planned administration of the vaccine candidate.
- Planned receipt of any vaccine (licensed or investigational), other than the study intervention, within 14 days before and after study vaccination
- Prior receipt of an investigational or licensed vaccine likely to impact on the interpretation of the trial data (e.g. Adenovirus vectored vaccines, any coronavirus or SARS vaccines)
- Administration of immunoglobulins and/or any blood products within the three months prior to the planned administration of the vaccine candidate
- Any confirmed or suspected immunosuppressive or immunodeficient state; positive HIV status; asplenia; recurrent severe infections and chronic use.
- History of allergic disease or reactions likely to be exacerbated by any component of Ad5-nCoV
- Any history of angioedema
- Any history of anaphylaxis to any vaccine component
- Pregnancy, lactation or willingness/intention to become pregnant during the study
- Current diagnosis of or treatment for cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ)
- History of serious psychiatric condition likely to affect participation in the study
- Suspected or known current alcohol or drug dependency
- Severe and/or uncontrolled cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder and neurological illness
- History of laboratory-confirmed COVID-19
- Any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data.
Key Trial Info
Start Date :
September 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 21 2022
Estimated Enrollment :
44247 Patients enrolled
Trial Details
Trial ID
NCT04526990
Start Date
September 15 2020
End Date
October 21 2022
Last Update
June 15 2023
Active Locations (74)
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1
Fundación Socolinsky Centro de Vacunación Proteger - Recoleta
CABA, Buenos Aires, Argentina, C1023AAO
2
Hospital Pirovano
CABA, Buenos Aires, Argentina, C1430BKC
3
Htal de Alta Complejidad Cuenca Alta Néstor Kirchner
Cañuelas, Buenos Aires, Argentina, 1814
4
Hospital Interzonal de Agudos "San Juan de Dios" de La Plata
La Plata, Buenos Aires, Argentina, 1900