Status:
COMPLETED
Liver Fat as a Dietary Target for Treating Cardiometabolic Disorders in Prediabetes and Type 2 Diabetes
Lead Sponsor:
Uppsala University
Conditions:
NAFLD
Diabetes Mellitus, Type 2
Eligibility:
All Genders
30-75 years
Phase:
NA
Brief Summary
The overall aim of this study is to investigate the long-term impact of a customized diet aimed at reducing liver fat specifically and a healthy Nordic diet on ectopic fat (liver, pancreatic and visce...
Detailed Description
Randomized controlled studies investigating the impact of replacing dietary carbohydrates with polyunsaturated fat (PUFA) on liver fat content and cardiometabolic risk in individuals with prediabetes ...
Eligibility Criteria
Inclusion
- Men and women
- 30-75 years
- BMI 25-40
- T2D (duration ≤10 years, no insulin treatment) or prediabetes (ADA definition 2019) without diagnosed cardiovascular disease (CVD) during the last 2 years (e.g. myocardial infarction, stroke or angina pectoris)
Exclusion
- BMI \>40
- Alcohol intake \>20 g/day
- Unwillingness to follow a new prescribed diet for 1 year
- Diet-induced weight loss (≥10%) the preceding 3 months of screening
- Malignant disease
- Severe kidney and liver disease
- Heart failure or other severe CVD
- claustrophobia or metal parts in the body (MRI)
Key Trial Info
Start Date :
August 11 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 20 2022
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04527965
Start Date
August 11 2020
End Date
December 20 2022
Last Update
December 22 2022
Active Locations (1)
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1
Uppsala univeristy hospital
Uppsala, Sweden, 75185