Status:
RECRUITING
Whole Genome Sequencing Versus Whole Exome Sequencing for Congenital Diarrhea and Enteropahty
Lead Sponsor:
Children's Hospital of Fudan University
Conditions:
Diarrhea, Infantile
Enteropathy
Eligibility:
All Genders
Up to 6 years
Phase:
NA
Brief Summary
This study will seek to determine if whole genome sequencing (WGS) improves diagnostic rates, and outcomes for congenital diarrhea and enteropathy (CODE) patients. The investigator will enroll 180 pat...
Eligibility Criteria
Inclusion
- Patients with chronic diarrhea lasting greater than 2 months
- Patients with consent from parents or legal guardians
- Biological relative of a patient enrolled in this study.
Exclusion
- Chronic diarrhea caused by specific infections, i.e. CMV, Clostridioides difficile
- Chronic diarrhea with necrotizing enterocolitis, short bowel syndrome
- Functional diarrhea
- Patients with previously confirmed monogenic diarrhea
- Patients with poor compliance
Key Trial Info
Start Date :
May 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04528303
Start Date
May 1 2024
End Date
December 1 2025
Last Update
September 5 2025
Active Locations (1)
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1
Ying Huang
Shanghai, Shanghai Municipality, China, 201102