Status:
COMPLETED
Digital Capillary Refill for Monitoring of Sepsis
Lead Sponsor:
Oregon Health and Science University
Conditions:
Sepsis
Eligibility:
All Genders
18-65 years
Brief Summary
Observational study for monitoring of capillary refill time in sepsis
Detailed Description
This is an observational studying assessing changes in capillary refill time over the course of sepsis treatment.
Eligibility Criteria
Inclusion
- Clinical evidence of a known or suspected infection and orders written for administration of IV antibiotics
- Hypotension as defined by the need for any vasopressor (and 1 liter of fluid already administered) OR respiratory failure defined by assisted ventilation (includes mechanical ventilation and BIPAP), CPAP, or greater than or equal to 6 liters/minute of supplemental oxygen
Exclusion
- No consent/inability to obtain consent from the participant or a legally authorized representative
- Diagnosis of cirrhosis by medical chart review
- Liver transplant recipient
- AST or ALT greater than five times upper limit of normal
- Diagnosis of ongoing chronic alcohol use disorder/abuse by chart review; if medical record unclear, use Appendix F
- Clinical diagnosis of diabetic ketoacidosis or other condition such as profound hypoglycemia that requires hourly blood glucose monitoring
- Hypersensitivity to Acetaminophen or Vitamin C
- Patient, surrogate or physician not committed to full support (Exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)
- Home assisted ventilation (via tracheotomy or noninvasive) except for CPAP/BIPAP used only for sleep-disordered breathing
- Current active kidney stone
- Known history of oxalate kidney stones or history of oxalate nephropathy
- Kidney transplant recipient
- Use of home oxygen for chronic cardiopulmonary disease
- Moribund patient not expected to survive 24 hours
- Underlying malignancy or other condition with estimated life expectancy of less than 1 month
- Pregnant woman, woman of childbearing potential without a documented negative urine or serum pregnancy test during the current hospitalization, or woman who is breast feeding
- Prisoner
- Enrollment in another critical care based pharmacologic interventional trial
- Treating team unwilling to enroll because of intended use of Acetaminophen or Vitamin C
Key Trial Info
Start Date :
August 12 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2023
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04529655
Start Date
August 12 2020
End Date
November 1 2023
Last Update
August 14 2025
Active Locations (1)
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1
OHSU
Portland, Oregon, United States, 97239