Status:
RECRUITING
Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma
Lead Sponsor:
CancerCare Manitoba
Collaborating Sponsors:
University of Manitoba
The Metabolomics Innovation Centre
Conditions:
Glioblastoma Multiforme
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Glioblastoma multiforme (GBM) is the most common brain tumor in adults. The strikingly poor survival for patients with GBM (average survival 14-16 months following diagnosis) is due in part to limited...
Detailed Description
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, with a median age of onset of 55 to 60 years. Most patients are treated with postoperative radiation and chemotherapy fol...
Eligibility Criteria
Inclusion
- Adult (18 years+)
- Pathologically confirmed Glioblastoma
- ECOG performance status 0-2
- Planned treatment with radiation and/or chemotherapy with temozolomide or lomustine
- Able to return to the study centre for study visits
- Able to swallow oral pills
- Serum creatinine and creatinine clearance (\>60mL/min)
- Liver enzymes for liver function (Liver function tests \<2.5 times the upper limit of normal)
- Participants of childbearing potential must agree to use an effective contraceptive method.
Exclusion
- Known hypersensitivity or allergy to amantadine
- Concurrent infection requiring antiviral medication
- Concurrent medication with known interaction with amantadine (see below)
- Previous diagnosis of Parkinson's disease or parkinsonism
- Previous diagnosis of schizophrenia
- Current use of methamphetamine or cocaine
- Inability to swallow oral pills
- Significant impairment in renal function (Creatinine clearance \< 60 mL/min)
- Women who are pregnant or are breastfeeding
Key Trial Info
Start Date :
December 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04530006
Start Date
December 2 2020
End Date
August 1 2025
Last Update
February 23 2024
Active Locations (1)
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1
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9