Inclusion Criteria, at least one of the following:

• Triaged as one of highest two triage categories (red or orange) according to the Manchester triage system;
• Triaged as the third highest triage category (yellow) and arrival by EMS of Helicopter Emergency Medical Service (HEMS;
• Shock
• Suspicion of sepsis (based on either physicians' suspicion, Sepsis-2 or Sepsis-3 criteria)
• Acute kidney injury (AKI)
• Anaphylactic reaction
• Syncope
• Intoxication
• Thrombosis
• Pulmonary embolism
• Bleeding while using anti-coagulant drugs
• Gastro-intestinal bleeding
• Electrolyte disturbance

Exclusion Criteria:

• Referred for organ transplantation as recipient
• Transfer from other hospital
• Accidental contact patient material (i.e. internal work-related accident)

While data- and imaging will be collected from all these patients, biomaterials will only be collected from patients fulfilling the first criterion (i.e. triaged as one of highest two triage categories [red or orange] according to the Manchester triage system) and from patients with shock or a suspicion of sepsis.